Markos Kampanis was born in 1955 in Athens. He studied painting in London, where he lived until 1980. He works in painting, printmaking, book illustration, murals and occasionally in stage design.

His work can be described as realist, though it incorporates a wide range of technical variations. His intense, almost fetishistic, interest in the materials and techniques of painting and printmaking operates alongside an academic interest in art history, which has led him to curate books and exhibitions. His subject matter is extensive, with landscapes, still lifes, trees, as well as the very process of painting itself and the world of his studio occupying a central place.

He has held numerous solo exhibitions and participated in many group exhibitions in Greece and abroad; in 1984 he took part in the 15th Alexandria Biennale. For several years his work focused on Mount Athos and was presented in a 2010 exhibition at the Byzantine and Christian Museum in Athens. In 2023–24, a major retrospective exhibition of his work was organized at the National Library of Greece and at the Teloglion Foundation of Arts in Thessaloniki. A series of works based on the Odyssey was presented in 2025 at the Benaki Museum.

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